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Related Concept Videos

Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Factors Affecting Drug Response: Overview01:21

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When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
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Prescription, Nonprescription and Orphan Drugs01:02

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
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Drug Distribution: Tissue Binding01:21

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Related Experiment Video

Updated: Aug 26, 2025

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Polypharmacy in the Homebound Population.

Erin Atkinson Cook1, Maria Duenas2, Patricia Harris1

  • 1UCLA Division of Geriatrics, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095, USA.

Clinics in Geriatric Medicine
|October 9, 2022
PubMed
Summary
This summary is machine-generated.

Homebound elders face challenges managing multiple chronic conditions and medications, a problem worsened by COVID-19. A team-based approach shows promise for improving medication management and quality of life for this growing population.

Keywords:
DeprescribingHome health agencyHome-based primary careHomeboundPharmacistPolypharmacyTeam-based

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Area of Science:

  • Gerontology
  • Public Health
  • Pharmacology

Background:

  • The population of homebound elderly individuals has significantly increased, exacerbated by the COVID-19 pandemic.
  • These individuals often present with multiple (≥5) chronic conditions and complex medication regimens (≥6 medications).
  • High-risk factors include functional decline, medication nonadherence, errors, interactions, and diminished quality of life due to polypharmacy.

Purpose of the Study:

  • To address the challenges of polypharmacy in homebound elders.
  • To explore the potential of a team-based approach for improving medication management in this demographic.

Main Methods:

  • Review of current literature on homebound elders, polypharmacy, and team-based care models.
  • Analysis of risk factors associated with complex medication regimens in elderly populations.

Main Results:

  • Polypharmacy is a significant burden, increasing risks of nonadherence, errors, and interactions.
  • A team-based care strategy is a potential solution for enhancing medication management.

Conclusions:

  • Effective management of polypharmacy is crucial for homebound elders' health and well-being.
  • Team-based interventions may offer a viable strategy to mitigate the risks associated with multiple medications in this vulnerable group.