Parameters of Hemodynamic Allostasis in Patients of Various Age Groups with Essential Arterial Hypertension

Area of Science:

• Cardiology
• Physiology
• Hypertension Research

Background:

• Essential arterial hypertension is a prevalent condition affecting cardiovascular health.
• Allostatic load and hemodynamic allostasis are key concepts in understanding the body's response to stress.
• Age-related changes in cardiovascular regulation are significant in hypertensive patients.

Purpose of the Study:

• To establish diagnostic criteria for hemodynamic allostasis in essential arterial hypertension.
• To compare hemodynamic allostasis with the allostatic load index in different age groups.
• To investigate the influence of age on hemodynamic allostasis and allostatic load in hypertensive patients without metabolic syndrome.

Main Methods:

• Inclusion of 87 subjects: hypertensive patients (<=60 and >60 years) and healthy controls.
• Utilizing 24-hour blood pressure (BP) monitoring.
• Applying linear and nonlinear rhythm analysis to BP data.

Main Results:

• Identified parameters for assessing allostatic regulation of 24-hour BP dynamics.
• Identified parameters defining allostatic hemodynamic load on the cardiovascular system.
• Hemodynamic regulation in hypertensive patients (without metabolic syndrome) consistently falls within hemodynamic allostasis, creating an allostatic load irrespective of age.

Conclusions:

• The study defines criteria for diagnosing hemodynamic allostasis and quantifies allostatic load.
• Hemodynamic allostasis and the resulting allostatic load are present in hypertensive patients across different age groups.
• Age does not appear to be a determining factor for the allostatic hemodynamic load in essential arterial hypertension without metabolic syndrome.