Related Experiment Video
Updated: Aug 26, 2025
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Lesion probability map in cerebral vein thrombosis due to Behçet's disease
Ahmed Serkan Emekli1, Faruk Uğur Doğan1, Tuncay Gündüz1
1Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Insights
Cerebral venous sinus thrombosis (CVST) is more common in Behçet's disease (BD) patients, particularly affecting the transverse sinus. This study visualizes CVST patterns to differentiate BD from other causes.
Area of Science:
- Neurology
- Vascular Medicine
- Radiology
Background:
- Behçet's disease (BD) is a multisystemic inflammatory condition.
- Cerebral venous sinus thrombosis (CVST) is a significant neurological manifestation of BD.
Purpose of the Study:
- To create flow-void probability maps for CVST patients with and without BD.
- To visually compare impacted cerebral venous sinuses between groups.
- To investigate the relationship between thrombus location and clinical presentation.
Main Methods:
- Inclusion of 17 patients with BD-related CVST (CVST-BD) and 23 with CVST from other causes (CVST-O).
- Collection of clinical data: gender, age, symptoms, neurological findings, and etiology.
- Utilizing high-resolution magnetic resonance venography to map thrombosed areas and generate probability/subtraction maps.
Main Results:
- All CVST-BD patients exhibited transverse sinus (TS) thrombosis.
- TS thrombosis occurred in 73.9% of CVST-O patients (p=0.03).
- Superior sagittal sinus (SSS) and TS thrombosis were most frequent in the CVST-O group.
Conclusions:
- Venous infarction and hemorrhage were less frequent in CVST-BD.
- Headache due to elevated intracranial pressure was the primary symptom in most CVST-BD patients.
- Transverse sinus thrombosis is more prevalent in Behçet's disease-associated CVST.
Aim:
Behçet's disease (BD) is a multisystemic inflammatory disease. Cerebral venous sinus thrombosis (CVST) is the second most common form of neuro-BD after parenchymal central nervous system involvement. The purpose of this study was to construct flow-void probability maps of patients with CVST with and without BD to visually illustrate the impacted cerebral venous sinuses, to compare the subgroups of patients, and investigate the effect of thrombus localization on clinical findings.
Methods:
Seventeen patients with a diagnosis of BD-related CVST (CVST-BD) and 23 patients with a diagnosis of CVST related to other etiologies (CVST-O) were included. We collected data including gender, age at onset of BD and CVST, presenting symptoms, neurological findings, and the etiology. High-resolution magnetic resonance venographies obtained during CVST were used to mark and digitalize thrombosed areas. Thrombus probability and subtraction maps were created to reveal the differences between the subgroups.
Results:
Remarkably, all patients with CVST-BD had thrombosis in the transverse sinus (TS). However, TS was affected in 73.9% of the CVST-O patients (17/17 in CVST-BD vs 17/23 in CVST-O, P = .03). Thrombosis developed mostly in the superior sagittal sinus (SSS) and TS in the CVST-O group (11/23, 47.8% and 17/23, 73.9%, respectively). The frequency of SSS thrombosis tended to be higher in the CVST-O (47.8% vs 23.5%, P = .19).
Conclusion:
Venous infarction and hemorrhage were less common in patients with CVST-BD. The only clinical symptom in most of the CSVT patients with BD was headache due to elevated intracranial pressure. TS thrombosis was more common in patients with BD.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
01:29Venous Thrombosis III: Interprofessional Care