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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.7K

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Updated: Aug 26, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Primary Intrasellar Amyloidoma.

Yongqiang Xu1, Haitao Zhang, Pengfei Liu

  • 1Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou, Shandong, China.

The Journal of Craniofacial Surgery
|October 10, 2022
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of an intrasellar amyloidoma, a non-pituitary tumor. Complete surgical resection via a transsphenoidal approach resolved the patient's symptoms and prevented recurrence.

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Area of Science:

  • Neurology
  • Pathology
  • Neurosurgery

Background:

  • Amyloidomas are uncommon neurological tumors, with primary intrasellar amyloidomas being exceptionally rare.
  • This case highlights the diagnostic and therapeutic challenges posed by these rare lesions in the sellar region.

Observation:

  • A 39-year-old male presented with headache due to a primary intrasellar amyloidoma.
  • Preoperative imaging (CT and MRI) was used to rule out other sellar pathologies.
  • Surgical findings revealed a yellow, crystalline, poorly vascularized, and unencapsulated tumor.

Findings:

  • The patient underwent successful endoscopic transsphenoidal tumor resection.
  • Postoperative pathological examination confirmed the diagnosis of amyloidoma, excluding pituitary adenoma.
  • The patient experienced complete symptom resolution and remained recurrence-free at 1-year follow-up.

Implications:

  • This case underscores the importance of considering amyloidoma in the differential diagnosis of sellar masses.
  • Endoscopic transsphenoidal surgery is a viable and effective treatment for intrasellar amyloidomas.
  • Complete resection appears to offer a favorable prognosis with no recurrence in this case.