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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Cancer-associated non-bacterial thrombotic endocarditis
Osnat Itzhaki Ben Zadok1, Galia Spectre2, Avi Leader2
1Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Thrombosis Research
|October 10, 2022
Summary
Cancer-associated non-bacterial thrombotic endocarditis (NBTE) involves sterile vegetations causing emboli. Early diagnosis and treatment of NBTE and its underlying cancer are crucial for managing this underdiagnosed condition.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Non-bacterial thrombotic endocarditis (NBTE) is characterized by sterile, platelet-fibrin vegetations on heart valves.
- NBTE is frequently associated with malignancy and can lead to systemic embolization, particularly stroke.
Purpose of the Study:
- To review current evidence on the pathogenesis, clinical manifestations, diagnosis, and management of cancer-associated NBTE.
- To highlight NBTE as an underdiagnosed cause of embolic stroke in cancer patients.
Main Methods:
- Literature review of existing evidence on cancer-associated NBTE.
- Analysis of clinical characteristics, diagnostic tools, and management strategies.
Main Results:
- Cancer is a leading cause of NBTE, with mucin-releasing adenocarcinomas being common culprits.
- NBTE poses a high risk for arterial thromboembolism (stroke) rather than valvular dysfunction.
- Diagnostic indicators include elevated D-dimer, infarcts in multiple territories, and microembolic signals; transesophageal echocardiography is key.
Conclusions:
- Cancer-associated NBTE is an underdiagnosed condition requiring prompt evaluation for malignancy.
- Management involves anticoagulation (low molecular weight heparin) and timely initiation of anti-cancer therapy.
- Further research is urgently needed due to limited data and severe clinical outcomes.
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