Alteration in serum oxidative stress balance in patients with different circulating high-density lipoprotein...

Area of Science:

• Biochemistry
• Cardiovascular Research
• Oxidative Stress

Background:

• High-density lipoprotein cholesterol (HDL-C) plays a key role in reverse cholesterol transport and is associated with atheroprotective effects.
• Low HDL-C is an independent risk factor for cardiovascular disease, premature atherosclerosis, and increased oxidative stress.
• The clinical benefits of elevated HDL-C remain under investigation.

Purpose of the Study:

• To investigate the relationship between isolated high HDL-C levels and markers of oxidative stress.
• To assess the role of arylesterase (ARES) activity and plasma thiol levels in patients with high HDL-C.
• To determine if oxidative stress status influences the beneficial effects of HDL-C.

Main Methods:

• The study included patients with isolated low HDL-C, isolated high HDL-C, and normal HDL-C controls.
• Exclusion criteria targeted conditions associated with increased oxidative stress and inflammation.
• Assessed laboratory parameters included arylesterase (ARES) activity, plasma thiol levels, and other oxidative stress markers.

Main Results:

• Patients with high HDL-C exhibited significantly higher levels of ARES activity and total thiols compared to controls.
• Total antioxidant capacity, oxidative stress index, and serum ARES levels were associated with serum HDL-C levels.
• In high HDL-C patients, other oxidative stress markers decreased markedly alongside elevated ARES and thiols.

Conclusions:

• Isolated high HDL-C is associated with increased serum ARES activity and plasma thiol concentrations.
• Serum oxidative stress status is critical for preserving the atheroprotective effects of HDL-C.
• These findings highlight the complex interplay between HDL-C, oxidative stress, and cardiovascular health.