Related Experiment Video
Updated: Aug 26, 2025
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
Low-Grade Appendiceal Mucinous Neoplasm: A Case Series
Andy S Wang1, Hussam N Ismael2, Jignesh Parikh3
1Surgery, University of Central Florida College of Medicine, Orlando, USA.
Abstract:
Low-grade appendiceal mucinous neoplasm (LAMN) is a lesion of the appendix with potentially fatal consequences if untreated. Though LAMN can be asymptomatic and stable, it can rupture and seed mucin and neoplastic epithelium into the peritoneum, leading to pseudomyxoma peritonei (PMP), a serious complication characterized by intraperitoneal accumulation of mucinous tumors and ascites with a high morbidity and mortality rate. Therefore, timely identification and treatment of LAMN are crucial for reducing PMP risk and improving prognosis and outcome. This case series sought to examine five LAMN cases and delineate the strategies for managing LAMN and progression to rupture and PMP.
Insights
Low-grade appendiceal mucinous neoplasm (LAMN) can rupture, causing pseudomyxoma peritonei (PMP). Early detection and management of LAMN are vital to prevent PMP and improve patient outcomes.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Low-grade appendiceal mucinous neoplasm (LAMN) is an appendiceal lesion with significant risks if left untreated.
- Untreated LAMN can rupture, leading to pseudomyxoma peritonei (PMP), a severe condition with high morbidity and mortality.
- Prompt diagnosis and intervention are essential for mitigating PMP risk and enhancing patient prognosis.
Related Concept Videos
01:22Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...