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Related Experiment Video

Updated: Aug 26, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Bullous Pemphigoid Complicated by Sepsis.

Dipal Shah1,2, Aanchal Shah3, Viet S Nguyen1

  • 1Emergency Medicine, HCA (Hospital Corporation of America) Florida Ocala Hospital, Ocala, USA.

Cureus
|October 10, 2022
PubMed
Summary
This summary is machine-generated.

Bullous pemphigoid management is challenging, especially in elderly patients due to corticosteroid risks. This case highlights a younger patient

Keywords:
blisteringblistersbulbous pemphigoidpruritissub-epithelial

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Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Bullous pemphigoid (BP) primarily affects the elderly, with corticosteroids as first-line treatment, increasing morbidity and mortality.
  • Managing BP involves balancing medication efficacy with patient comorbidities and risks like infection, pruritus, and pain.

Observation:

  • A 38-year-old female with a history of bullous pemphigoid and multiple medical problems presented with nausea, vomiting, fever, abdominal pain, and forearm blisters.
  • The patient's presentation raised concerns for sepsis, complicated by her bullous pemphigoid and prior treatment failures.

Findings:

  • Hospitalization was necessary for managing potential sepsis, bullous pemphigoid exacerbation, and associated symptoms.
  • Treatment addressed infection, bullous pemphigoid, nausea, vomiting, and pain.

Implications:

  • This case underscores the complexity of bullous pemphigoid management, even in younger patients with comorbidities.
  • It emphasizes the need for careful consideration of infection risk and tailored treatment strategies in bullous pemphigoid patients.