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Updated: Jul 31, 2026
14:05
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
Published on: December 20, 2014
Nonoperative urinary diversion for malignant ureteral obstruction
Cancer
|September 15, 1987
Summary
Newer percutaneous drainage and endoscopic ureteral stenting techniques offer less morbid management for malignant ureteral obstruction (MUO). These advancements improve patient survival and reduce the need for open surgical procedures.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Malignant ureteral obstruction (MUO) management has evolved significantly.
- Traditional surgical methods for MUO were associated with high morbidity.
Purpose of the Study:
- To evaluate the impact of new percutaneous drainage and endoscopic ureteral stenting techniques on MUO management.
- To compare the outcomes of newer minimally invasive procedures with conventional open surgical techniques.
Main Methods:
- Retrospective analysis of 135 patients with unilateral or bilateral MUO managed between 1978 and 1984.
- Comparison of outcomes including success rates, morbidity, and survival following different diversion techniques (retrograde stenting, percutaneous nephrostomy, antegrade stenting, open procedures).
Main Results:
- Initial retrograde ureteral stenting (RS) had a 41% success rate under local anesthesia.
- Percutaneous nephrostomy (PN) followed by antegrade stenting (AS) allowed elimination of external appliances in some cases.
- Open procedures had a 57% morbidity rate, significantly higher than newer techniques.
- Mean survival post-diversion was 9.9 months, longer than with open procedures.
Conclusions:
- Malignant ureteral obstruction can now be effectively managed with minimal morbidity using percutaneous and endoscopic techniques.
- These less invasive methods frequently avoid the need for external urine collection devices.
- The ease of diversion with newer techniques may complicate decision-making in patients with bilateral MUO and progressive renal failure.
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