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Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea
Joan Kim1, Seung Woo Choi1, Young Shin Lee1
1Department of Cardiology, Kyung Hee University Hospital, Seoul, Korea.
Insights
Lipoprotein(a) levels were not associated with coronary artery disease or coronary artery calcium scores in this Korean study. However, high coronary artery calcium scores did correlate with coronary revascularization.
Area of Science:
- Cardiology
- Biomarkers
- Medical Imaging
Background:
- Lipoprotein(a) (Lp(a)) is linked to coronary artery disease (CAD) and aortic valve calcification.
- Understanding Lp(a)'s role in coronary artery calcium (CAC) is crucial for risk stratification.
Purpose of the Study:
- To investigate the correlation between Lp(a) levels and CAC scores.
- To determine the association between Lp(a) and CAD in patients undergoing coronary computed tomography angiography (CCTA).
Main Methods:
- Single-center observational study of 252 patients without prior CAD diagnosis.
- Patients underwent CCTA and Lp(a) measurement within three months.
- Analysis included dividing patients by Lp(a) levels (50 mg/dL) and CAC scores (400).
Main Results:
- No significant relationship was found between Lp(a) levels and CAD or other CAD risk factors.
- No differences in coronary revascularization rates or CAC scores were observed based on Lp(a) levels.
- A high CAC score was significantly correlated with coronary revascularization (50.6% vs 23.7%).
- Spearman correlation showed no association between Lp(a) level and CAC score (p < 0.998).
Conclusions:
- Lp(a) levels were not associated with CAC score or CAD in this Korean cohort.
- High CAC scores were strongly correlated with the need for coronary revascularization.
- Further research may be needed to clarify Lp(a)'s role in specific populations.
Background:
Lipoprotein(a) (Lp(a)) levels are associated with coronary artery disease (CAD) and aortic valve calcification. This study aimed to determine the correlation between Lp(a) levels and coronary artery calcium (CAC) scores in patients who underwent coronary computed tomography angiography (CCTA).
Methods:
This was a single-center observational study. The patients had not been previously diagnosed with CAD and underwent CCTA and Lp(a) measurement in a three-month timeframe. Coronary angiography and further management were performed according to the physician's decision. Of the 252 patients, 81 and 171 patients underwent coronary revascularization and received medical treatment only, respectively. To examine the relationship between Lp(a) and CAC score and between Lp(a) and CAD, we divided the patients by Lp(a) level (50 mg/dL) and CAC score (400).
Results:
No relationship was observed between Lp(a) and CAD or other risk factors for CAD. There were no differences in the ratio of patients who underwent coronary revascularization or in the CAC score according to an Lp(a) level of 50 mg/dL. There was no difference in Lp(a) level at a CAC score of 400. The proportion of patients who underwent coronary revascularization was high in the high CAC score group (50.6% vs 23.7%, p = 0.000). No association was observed between Lp(a) level and CAC score in the Spearman correlation (0.000, p < 0.998).
Conclusion:
Correlations between Lp(a) level and CAC score and between Lp(a) and CAD were not observed in this Korean cohort study. However, a high CAC score was correlated with coronary revascularization.
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