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RELATION OF APELIN, TUMOR NECROSIS FACTOR ALPHA AND CLAUDIN-5 TO BODY MASS INDEX IN CHOLECYSTECTOMIES
Acta Endocrinologica (Bucharest, Romania : 2005)
|October 10, 2022
Summary
Body Mass Index (BMI) correlates positively with Tumor Necrosis Factor Alpha (TNF-α) staining in chronic cholecystitis patients. Claudin-5 and Apelin showed no significant relationship with BMI or inflammation in this study.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Chronic cholecystitis is a common gallbladder condition.
- Obesity, indicated by Body Mass Index (BMI), is a growing health concern.
- Inflammatory markers and specific proteins may play a role in cholecystitis pathogenesis.
Purpose of the Study:
- To investigate the association between Claudin-5, Apelin, Tumor Necrosis Factor Alpha (TNF-α) expression, and BMI in patients with chronic cholecystitis.
- To determine if these molecular markers correlate with obesity in the context of gallbladder inflammation.
Main Methods:
- Analysis of 68 paraffin-embedded chronic cholecystitis specimens.
- Immunohistochemical staining for Apelin, Claudin-5, and TNF-α.
- Correlation analysis between protein expression, BMI, and other clinical parameters.
Main Results:
- A significant positive correlation was observed between BMI and TNF-α staining intensity (p=0.010).
- BMI showed a significant correlation with blood glucose levels (p=0.029).
- No statistically significant correlations were found between BMI and Claudin-5 or Apelin expression.
Conclusions:
- BMI is significantly associated with TNF-α expression in chronic cholecystitis.
- Claudin-5 and Apelin do not appear to be related to BMI or inflammation in this patient cohort.
- These findings suggest a potential role for TNF-α in the interplay between obesity and chronic cholecystitis.
