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Updated: Aug 26, 2025

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
PATHOLOGICALLY-CONFIRMED ISOLATED HYPOTHALAMO-PITUITARY SARCOIDOSIS REFRACTORY TO PULSE-DOSE GLUCOCORTICOIDS AND
B Borawski1, P Kuca1, G Zieliński2
1Medical University of Warsaw, Department of Internal Medicine, Endocrinology and Diabetes.
Isolated sarcoidosis affecting the brain's pituitary gland is rare. Methotrexate proved effective for a patient with panhypopituitarism unresponsive to steroids, suggesting its potential as a second-line therapy for this condition.
Area of Science:
- Endocrinology
- Neurology
- Immunology
Background:
- Isolated sarcoidosis of the hypothalamic-pituitary system is an exceptionally rare manifestation of neurosarcoidosis.
- Diagnosis requires a high index of suspicion, and treatment protocols are not standardized.
- Initial treatment typically involves glucocorticoids, with immunomodulators, cytotoxic drugs, and monoclonal antibodies as second or third-line options.
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