Related Experiment Video

Updated: Aug 26, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Glucocorticoid receptor and androgen receptor-targeting therapy in patients with castration-resistant prostate cancer

Sahyun Pak1, Jungyo Suh2, Seo Young Park3

  • 1Department of Urology, Hallym University College of Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea.

Frontiers in Oncology
|October 10, 2022
PubMed
Abstract

Insights

Glucocorticoid receptor (GR) expression levels predict treatment response in castration-resistant prostate cancer (CRPC). Lower GR/androgen receptor (AR)-FL ratios correlate with better outcomes to AR-targeting therapies and improved survival for CRPC patients.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • The glucocorticoid receptor (GR) can drive resistance to androgen receptor (AR)-targeting therapies in castration-resistant prostate cancer (CRPC) by circumventing AR blockade.
  • The clinical significance of assessing GR expression in CRPC patients remains unclear.

Purpose of the Study:

  • To investigate the association between relative GR expression in CRPC tissue and treatment response to AR-targeting therapy.

Main Methods:

  • GR, AR-FL, and AR-V7 mRNA levels were quantified in prostate cancer tissue from CRPC patients initiating treatment.
  • Patients were stratified into high/low ratio groups for AR-V7/AR-FL and GR/AR-FL.
  • The primary endpoint was prostate-specific antigen (PSA) response rate.

Main Results:

  • Higher PSA response rates were observed in patients with low GR/AR-FL ratios (81.3%) compared to high ratios (27.3%, p=0.003).
  • Low GR/AR-FL ratios were associated with improved PSA progression-free survival, radiologic progression-free survival, and overall survival.
  • The association between GR/AR-FL ratio and PSA response remained significant in multivariable analyses.

Conclusions:

  • Relative GR expression is linked to sensitivity to AR-targeting therapy and survival in CRPC patients.
  • Further large-scale prospective validation and liquid biopsy studies are recommended.
Keywords:
androgen receptorscastration-resistant prostate cancerglucocorticoid receptorssurvival analysistreatment outcome

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