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L-carnitine versus Propranolol for pediatric migraine prophylaxis
Laya Amini1, Omid Yaghini2, Mohammadreza Ghazavi2
1Department of Pediatrics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Iranian Journal of Child Neurology
|October 10, 2022
Summary
L-carnitine supplementation effectively reduced migraine frequency and severity in children. This study found L-carnitine to be as effective as propranolol in preventing pediatric migraine attacks.
Area of Science:
- Neurology
- Pediatric Medicine
- Biochemistry
Background:
- Carnitine is crucial for fatty acid transport in mitochondria.
- Carnitine has demonstrated a prophylactic effect against adult migraine.
Purpose of the Study:
- To compare L-carnitine supplementation with propranolol for preventing pediatric migraine.
- To evaluate the efficacy of L-carnitine in pediatric migraine management.
Main Methods:
- A randomized controlled trial involving 60 pediatric patients with episodic migraine.
- Patients received either L-carnitine (50 mg/kg/day) or propranolol (1 mg/kg/day) for 12 weeks.
- Assessed migraine frequency, severity, duration, and disability (PedMIDAS).
Main Results:
- Both L-carnitine and propranolol significantly decreased migraine frequency, severity, and duration.
- Migraine frequency reduced from 11.4 to 5.34 per month in the L-carnitine group.
- Headache severity scores significantly decreased in both treatment groups.
Conclusions:
- L-carnitine supplementation is a viable prophylactic option for pediatric migraine.
- No significant difference in efficacy was observed between L-carnitine and propranolol.
- L-carnitine plays a prophylactic role in managing pediatric migraine.
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