Related Experiment Video

Updated: Aug 26, 2025

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.8K

Chronic kidney disease in patients with congenital heart disease: a nationwide, register-based cohort study

Mikaela Gillesén1, Maria Fedchenko1, Kok Wai Giang1,2

  • 1Department of Molecular & Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Blå stråket 5B, SE-41345 Gothenburg, Sweden.

European Heart Journal Open
|October 10, 2022
PubMed

Insights

Young patients with congenital heart disease (CHD) have a significantly higher risk of developing chronic kidney disease (CKD). This increased risk persists even after accounting for other health conditions, highlighting the need for closer monitoring.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Congenital heart disease (CHD) affects individuals from birth, with potential long-term health implications.
  • Chronic kidney disease (CKD) is a progressive condition that can lead to serious health complications.
  • Understanding the interplay between CHD and CKD is crucial for comprehensive patient care.

Purpose of the Study:

  • To assess the risk of developing chronic kidney disease (CKD) in young patients diagnosed with congenital heart disease (CHD).
  • To compare the incidence of CKD in CHD patients against a matched cohort without CHD.
  • To identify specific CHD defect types associated with a higher CKD risk.

Main Methods:

  • Utilized data from the Swedish National Patient Register and Cause of Death Register.
  • Identified 71,936 CHD patients (born 1970-2017) and matched each to 10 controls without CHD.
  • Conducted a median follow-up of 13.5 years, collecting data until 2017.

Main Results:

  • Patients with CHD had a 6.4 times higher risk of developing CKD compared to controls.
  • Severe non-conotruncal defects showed the highest CKD risk (HR: 11.31).
  • The risk of CKD remained significantly elevated (HR: 4.37) after adjusting for hypertension, acute kidney injury, and diabetes.

Conclusions:

  • Young patients with CHD face a substantially increased risk of CKD, even with a relatively low absolute risk.
  • The findings underscore the importance of proactive CKD screening and management in CHD populations.
  • Further research is needed to develop specific guidelines for CKD prevention and follow-up in CHD patients.
Abstract

Keywords:
AdultsChildrenChronic kidney diseaseCongenital heart disease

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

787
Implantation of Total Artificial Heart in Congenital Heart Disease07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.7K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
57
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
64
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
71
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
44
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
53
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
60