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The intersection between toxicology and aging research: A toxic aging coin perspective
1NeuroWise Laboratory of Environmental Neurotoxicology, Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, United States.
Frontiers in Aging
|October 10, 2022
Summary
Environmental pollution poses risks to the aging population, yet geriatric considerations are missing in toxicology. This study introduces the "toxic aging coin" concept to assess chemical impacts on aging and aging
Area of Science:
- Environmental toxicology
- Gerontology
- Aging research
Background:
- Increasing lifespans and environmental pollution create health challenges for the aging population.
- Geriatric populations are underrepresented in environmental regulations and toxicology research.
- Adverse health effects in the elderly may stem from environmental exposures, but this is poorly understood.
Purpose of the Study:
- To introduce the
Main Methods:
- Proposes a unified animal study approach to investigate both sides of the toxic aging coin.
- Recommends assessing basic toxicology and aging-focused endpoints across multiple age groups.
- Focuses on the brain as a model system, with potential for broader organ system application.
Main Results:
- The concept of gerontogens (chemicals accelerating aging) is highlighted.
- The "toxic aging coin" framework integrates age-dependent toxic outcomes and chemical-induced aging.
- A single study design can address both aspects of chemical exposure and aging.
Conclusions:
- There is a critical need to incorporate aging into toxicology research.
- The "toxic aging coin" provides a framework for evaluating environmental risks in aging populations.
- Future research should utilize multi-age group studies to understand chemical impacts on aging.
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