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Successful aging after elective surgery II: Study design and methods.

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Summary
This summary is machine-generated.

The SAGES II study investigates biomarkers linking delirium and dementia in older adults undergoing surgery. It uses advanced imaging and neurophysiologic markers to understand cognitive decline post-operation.

Keywords:
biomarkerscognitive declinecognitive impairmentdeliriumdementialong-term cognitive decline

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Area of Science:

  • Gerontology
  • Neuroscience
  • Clinical Research

Background:

  • The Successful Aging after Elective Surgery (SAGES) II study aims to elucidate the pathophysiology and connections between delirium and dementia.
  • Novel biomarkers, including inflammation, Alzheimer's disease (AD) pathology, neurodegeneration, neuroimaging, and neurophysiologic markers, are examined.

Purpose of the Study:

  • To describe the study design and methods of the SAGES II study.
  • To investigate the relationship between delirium and dementia in older adults undergoing elective surgery.

Main Methods:

  • A 5-year prospective observational study involving 400-420 community-dwelling individuals aged 65 years and older.
  • Assessment includes the Confusion Assessment Method (CAM) for delirium, a neuropsychologic test battery for cognitive function (General Cognitive Performance score), MRI, TMS/EEG, and Amyloid PET imaging.
  • Data collection occurs pre-surgery and daily during hospitalization, with follow-up assessments at 1, 2, 6, 12, and 18 months.

Main Results:

  • The study details hospital and surgery variables, delirium incidence, long-term cognitive decline, clinical outcomes, and novel biomarkers.
  • High inter-rater reliability was achieved for CAM (kappa=0.91) and GCP (kappa=0.99) ratings.
  • Procedures for data quality assurance and adaptations for COVID-19 are described.

Conclusions:

  • This study offers an innovative approach to understanding the delirium-dementia inter-relationship in older surgical patients.
  • Integration of advanced imaging (MRI, PET) and neurophysiologic (TMS/EEG) modalities provides high-quality longitudinal data.
  • The findings contribute to advancing knowledge on cognitive changes associated with surgery in the elderly.