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Updated: Aug 26, 2025
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
A Case of "Cryptammonia": Disseminated Cryptococcal Infection Generating Profound Hyperammonemia in a Liver
Steven M Phillips1, Stephanie M Pouch1, Denise J Lo1
1Emory University, Atlanta, GA, USA.
Abstract:
Mycoplasma and Ureaplasma infections have been described as a cause of hyperammonemia syndrome leading to devastating neurological injury in the post-transplant period, most commonly in lung transplant recipients. The occurrence of significant hyperammonemia caused by other urease-producing organisms remains unclear. We describe a case of disseminated cryptococcosis presenting with profound hyperammonemia in a 55-year-old orthotopic liver transplant recipient. Through a process of elimination, other potential causes for hyperammonemia were excluded revealing a probable association between hyperammonemia and disseminated cryptococcosis.
Insights
Disseminated cryptococcosis can cause severe hyperammonemia in liver transplant patients. This case highlights a potential link between this fungal infection and elevated ammonia levels, even without other common causes.
Area of Science:
- Infectious Diseases
- Transplant Medicine
- Nephrology
Background:
- Hyperammonemia post-transplant is often linked to Mycoplasma and Ureaplasma infections.
- The role of other urease-producing organisms in post-transplant hyperammonemia is not well-established.
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