Related Experiment Video

Updated: Aug 26, 2025

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency
11:13

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

4.2K

In vitro measurement of ciliary beat frequency in 92 children with recurrent respiratory tract problems

A Drake-Lee1,2, A Green2, A-L McDermott1

  • 1Department of Otolaryngology, Birmingham Children's Hospital, UK.

The Journal of Laryngology and Otology
|October 10, 2022
PubMed

Insights

Measuring ciliary beat frequency aids in diagnosing chronic respiratory issues in children. This diagnostic tool helps identify conditions like asthma and bronchiectasis, improving patient outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Diagnostic Medicine

Background:

  • Chronic or recurrent mucoid respiratory tract symptoms present diagnostic challenges.
  • Accurate diagnosis is crucial for effective management of pediatric respiratory conditions.

Purpose of the Study:

  • To evaluate the utility of ciliary beat frequency measurement in diagnosing chronic respiratory symptoms in children.
  • To assess the relationship between ciliary function and specific respiratory conditions.

Main Methods:

  • Ninety-two children with chronic respiratory symptoms were categorized into four groups: refractory asthma, bronchiectasis, dextrocardia, and recurrent respiratory tract infections.
  • Ciliary beat frequency was measured using photometric analysis under general anesthesia.
  • The impact of temperature on ciliary beat frequency was assessed.

Main Results:

  • Twenty-six children exhibited absent ciliary beating.
  • A statistically significant difference in ciliary beat frequency was observed at different temperatures (p = 0.0003).
  • Nasal polyps were identified in one child with normal ciliary beat frequency.

Conclusions:

  • Ciliary beat frequency measurement is a valuable component in the diagnostic workup for children with persistent or recurrent respiratory tract infections.
  • Abnormal ciliary function may be indicative of underlying respiratory pathology.
Abstract

Keywords:
AsthmaBronchiectasisCiliary Motility DisordersKartagener SyndromeNasal PolypsOtitis Media With Effusion

More Related Videos

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

21.1K
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

4.9K

Related Concept Videos

Assessment of Ventilation I: Respiratory Rate01:20

Assessment of Ventilation I: Respiratory Rate

Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
1.2K
Special considerations while measuring oxygen saturation01:19

Special considerations while measuring oxygen saturation

Assessing respiratory rate concurrently with pulse measurement is fundamental to patient care, providing valuable insights into the patient's respiratory function. The normal breathing rate for an adult usually falls within a normal range of 12 to 20 breaths per minute. Abnormal respiratory rates can signal underlying health conditions or the need for immediate intervention.
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
652
Assessment of Ventilation II: Respiratory Depth and Rhythm01:29

Assessment of Ventilation II: Respiratory Depth and Rhythm

Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
1.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K