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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Bidirectional association between SBP variability and arterial stiffness in patients with chronic kidney disease:

Cheol Ho Park1, Hyung Woo Kim1, Jung Tak Park1

  • 1Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul.

Journal of Hypertension
|October 10, 2022
PubMed

Insights

High blood pressure variability and arterial stiffness are linked in chronic kidney disease patients. This bidirectional relationship suggests managing both is crucial for cardiovascular health in CKD.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Hypertension Research

Background:

  • Arterial stiffness and blood pressure (BP) variability are key cardiovascular risk factors.
  • Limited research exists on the dynamic interplay between BP variability and arterial stiffness, particularly in chronic kidney disease (CKD).

Purpose of the Study:

  • To investigate the bidirectional association between visit-to-visit systolic blood pressure variability (VVSV) and arterial stiffness in patients with CKD.
  • To determine if increased VVSV predicts the progression of arterial stiffness and if baseline arterial stiffness predicts future VVSV.

Main Methods:

  • A prospective cohort study of 1036 Korean patients with CKD (G1-G5) without kidney replacement therapy.
  • Brachial-ankle pulse wave velocity (baPWV) measured at baseline and 4 years; VVSV calculated as the standard deviation of SBP readings over 4 years.
  • Multivariable logistic regression models used to assess arterial stiffness progression (≥75th percentile of baPWV change) based on VVSV tertiles, and high VVSV based on baseline baPWV tertiles.

Main Results:

  • Higher VVSV was significantly associated with an increased risk of arterial stiffness progression (OR 1.64 for highest tertile vs. lowest).
  • Higher baseline arterial stiffness was also associated with increased VVSV (OR 1.64 for highest tertile vs. lowest).
  • These associations remained consistent when VVSV and baPWV were analyzed as continuous variables.

Conclusions:

  • A significant bidirectional relationship exists between blood pressure variability and arterial stiffness in patients with chronic kidney disease.
  • Findings highlight the importance of monitoring and managing both BP variability and arterial stiffness in CKD management.
  • This study provides novel insights into the complex cardiovascular pathophysiology in CKD patients.
Abstract

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