Three new rotenoids from the stems of Derris elliptica and their anti-microbial activity

Three new rotenoids, named derieliptosides A-C (1-3), were isolated from the stems of Derris elliptica (Wall.) Benth. Their structures were determined by HR-ESI-MS and NMR spectroscopic methods. Absolute configurations of them were elucidated by analysis of ECD spectra in comparison with TD-DFT calculation. Compounds 1-3 inhibited the growth of fungus Candida albicans and selectively inhibited bacterial strains. Of these, compound 1 showed selective inhibition on the growth of Enterococcus faecalis (MIC: 37.5 µM and IC₅₀: 10.6 µM), Staphylococcus aureus (MIC: 75 µM and IC₅₀: 22.7 µM), and C. albicans (MIC: 37.5 µM and IC₅₀: 11.2 µM).