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One Hundred Carboxylate Receptors.

Alo Rüütel1, Sofja Tshepelevitsh1, Ivo Leito1

  • 1Institute of Chemistry, University of Tartu, Ravila 14a, 50411Tartu, Estonia.

The Journal of Organic Chemistry
|October 10, 2022
PubMed
Summary

This study compiles 489 binding constants for 100 anion receptors and 12 carboxylate anions. The data aids in selecting receptors for carboxylate sensing applications, like ion-selective electrodes.

Area of Science:

  • Supramolecular Chemistry
  • Analytical Chemistry
  • Chemical Sensing

Background:

  • Carboxylate anions are prevalent in biological and environmental systems.
  • Developing selective and sensitive methods for carboxylate detection is crucial.
  • Anion receptor design is key for effective carboxylate sensing.

Purpose of the Study:

  • To create a comprehensive database of binding constants (log K_ass) for anion receptors and carboxylate anions.
  • To facilitate the selection of optimal receptor candidates for practical carboxylate sensing applications.
  • To provide essential data, including lipophilicity (log P_o/w), for informed receptor selection.

Main Methods:

  • Compilation of existing binding constant (log K_ass) data from scientific literature.

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  • Inclusion of newly measured binding constants for novel receptor molecules.
  • Systematic data collection over an 8-year period.

    • Main Results:

    • A dataset of 489 binding constant (log K_ass) values for 100 anion receptor molecules.
    • The data covers 12 different carboxylate anions, including common and pharmaceutical compounds.
    • Lipophilicity (log P_o/w) data is provided for all listed receptors.

    Conclusions:

    • This compilation serves as a valuable resource for researchers in supramolecular chemistry and analytical sensing.
    • The data supports the rational design and selection of receptors for carboxylate detection.
    • The findings are directly applicable to the development of advanced carboxylate sensing technologies, such as ion-selective electrodes.