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Developing therapeutic approaches for chronic myeloid leukemia: a review
Veerandra Kumar1, Jyotirmayee1, Malkhey Verma2
1School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Molecular and Cellular Biochemistry
|October 10, 2022
Summary
Chronic myeloid leukemia (CML) treatment with tyrosine kinase inhibitors (TKIs) faces challenges due to resistance and intolerance. New TKIs and combination therapies show promise for improving CML chemotherapy outcomes.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Chronic myeloid leukemia (CML) is a severe hematologic malignancy.
- Tyrosine kinase inhibitors (TKIs) are effective but limited by resistance and intolerance.
- Stem cell transplantation has limitations, particularly in older patients.
Purpose of the Study:
- To review current and emerging treatment strategies for CML.
- To explore the efficacy of TKIs in combination with other therapies.
- To investigate approaches for overcoming TKI resistance and intolerance.
Main Methods:
- Review of clinical trials and preclinical studies on CML treatments.
- Investigation of TKI combinations with interferon and chemotherapy agents.
- Analysis of targeted therapies for TKI-resistant CML cell signaling pathways.
Main Results:
- New TKIs in clinical trials demonstrate potential to enhance CML chemotherapy.
- Combination strategies may overcome resistance and intolerance to current TKIs.
- Targeting upregulated signaling pathways in resistant CML cells is a viable approach.
Conclusions:
- Continuous research into CML biology is crucial for developing novel treatments.
- Emerging TKIs and combination therapies offer improved therapeutic options for CML.
- Addressing TKI resistance and intolerance remains a key challenge in CML management.
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