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Updated: Aug 26, 2025

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses
Published on: January 12, 2024
New insights into disordered proteins and regions according to the FOD-M model
Irena Roterman1, Katarzyna Stapor2, Piotr Fabian3
1Department of Bioinformatics and Telemedicine, Jagiellonian University, Medical College, Kraków, Poland.
Abstract:
A collection of intrinsically disordered proteins (IDPs) having regions with the status of intrinsically disordered (IDR) according to the Disprot database was analyzed from the point of view of the structure of hydrophobic core in the structural unit (chain / domain). The analysis includes all the Homo Sapiens as well as Mus Musculus proteins present in the DisProt database for which the structure is available. In the analysis, the fuzzy oil drop modified model (FOD-M) was used, taking into account the external force field, modified by the presence of other factors apart from polar water, influencing protein structuring. The paper presents an alternative to secondary-structure-based classification of intrinsically disordered regions (IDR). The basis of our classification is the ordering of hydrophobic core as calculated by the FOD-M model resulting in FOD-ordered or FOD-unordered IDRs.
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