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Oxidative versus reductive stress: a delicate balance for sperm integrity.
Niloofar Sadeghi1,2, Guylain Boissonneault1, Marziyeh Tavalaee2
1Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada.
Systems Biology in Reproductive Medicine
|October 10, 2022
Summary
Reductive stress, caused by excess reductants, can harm sperm and contribute to male infertility. This review explores reductive stress mechanisms and their impact, contrasting them with oxidative stress.
Area of Science:
- Reproductive Biology
- Biochemistry
- Oxidative Stress Research
Background:
- Oxidative stress from reactive oxygen species (ROS) is a known factor in male infertility.
- Emerging evidence implicates reductive stress, caused by reductant over-accumulation, in cellular damage.
Conclusions:
- Reductive stress is a potential contributor to male infertility, acting at pre- and post-testicular levels.
- Understanding reductive stress is crucial for developing new therapeutic strategies beyond traditional antioxidant therapy.
- Dietary supplementation warrants careful consideration regarding its impact on reductive stress levels.
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