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Altered monocyte function in patients with benign breast disease.

A M Al-Sumidaie, S J Leinster, S A Jenkins

    Clinical and Experimental Immunology
    |January 1, 1987
    PubMed
    Summary

    Monocyte function, including migration and phagocytosis, is impaired in women with benign breast conditions like fibroadenosis and fibroadenoma. This suggests an intrinsic cellular defect may play a role in the pathophysiology of these common breast diseases.

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    Area of Science:

    • Immunology
    • Oncology
    • Pathophysiology

    Background:

    • Benign breast conditions such as fibroadenosis and fibroadenoma are common in women.
    • The role of immune cell function in the development of benign breast disease is not fully understood.

    Purpose of the Study:

    • To investigate monocyte function (migration, lysozyme production, phagocytosis) in patients with fibroadenosis and fibroadenoma.
    • To compare monocyte function in patients with benign breast disease to healthy controls.
    • To explore potential causes of altered monocyte function in benign breast disease.

    Main Methods:

    • Studied monocyte migration, lysozyme production, and phagocytosis.
    • Included 34 patients with fibroadenosis, 28 with fibroadenoma, and 48 healthy female controls.

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  • Assessed monocyte function before and after surgery in a subset of patients.

    • Main Results:

    • Significantly reduced monocyte migration and phagocytic activity in patients with fibroadenosis and fibroadenoma compared to controls (P < 0.001).
    • Significantly higher lysozyme production by monocytes in patients with benign breast disease compared to controls (P < 0.001).
    • No significant change in monocyte function observed 3 months post-operation in patients with benign breast disease.

    Conclusions:

    • Impaired monocyte function in fibroadenosis and fibroadenoma is likely due to an intrinsic cellular defect, not abnormal blood biochemistry or serum inhibitors.
    • Further research is needed to determine the significance of impaired monocyte function in the pathophysiology of benign breast disease.