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Stem cell microencapsulation maintains stemness in inflammatory microenvironment.

Yajun Zhao1,2, Yilin Shi1, Huiqi Yang1

  • 1Department of Implantology &amp; Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China.

International Journal of Oral Science
|October 10, 2022
PubMed
Summary
This summary is machine-generated.

This study developed a metal-phenolic network (MPN) nanofilm to encapsulate stem cell spheroids, protecting them in inflammatory environments. This novel microcapsule strategy maintains stemness for enhanced regenerative medicine therapies.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Maintaining stem cell stemness in inflammatory environments is crucial for regenerative medicine, especially for periodontal defects.
  • Direct stem cell delivery faces challenges due to the complex inflammatory milieu of periodontal tissues.

Purpose of the Study:

  • To develop a novel microencapsulation strategy for protecting stem cell spheroids and maintaining their stemness.
  • To create a biodegradable metal-phenolic network (MPN) biointerface for stem cell delivery in inflammatory conditions.

Main Methods:

  • Stem cell spheroids, specifically periodontal ligament stem cells (PDLSCs), were encapsulated using an interfacial assembly of a Fe(III)/tannic acid (TA) coordination network.
  • The resulting spheroid@[Fe(III)-TA] microcapsules were characterized for their protective and functional properties.

Main Results:

  • The biodegradable MPN biointerface effectively protected stem cell spheroids.
  • The microcapsules demonstrated antioxidative, antibacterial, and anti-inflammatory activities, remodeling the inflammatory microenvironment.
  • Stemness of PDLSCs within the microcapsules was successfully maintained.

Conclusions:

  • Stem cell microencapsulation using MPN nanofilms offers a promising strategy for maintaining stemness in inflammatory environments.
  • This approach provides a simple, efficient delivery system for regenerative medicine, applicable to various stem cells and metal-polyphenol combinations.