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Updated: Aug 26, 2025

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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
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Intratumour heterogeneity, from hypothesis to the clinic
Naing Lin Shan1, Adriana Kahn1, Lajos Pusztai2
1Yale Cancer Center, Yale School of Medicine, 333 Cedar St., PO Box 208032, New Haven, CT, 05620, USA.
British Journal of Cancer
|October 10, 2022
Abstract:
Recent technological advances uncovered intricate biological processes underlying intratumor heterogeneity with clinical implications. These insights led to novel biomarkers for immunotherapies, justified serial tumour biopsies for therapeutic target profiling, inspired new treatment strategies, and ultimately might yield novel therapeutics that target clonal interdependence.

