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Precision medicine: the precision gap in rheumatic disease

Chung M A Lin1, Faye A H Cooles1, John D Isaacs2,3

  • 1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Nature Reviews. Rheumatology
|October 10, 2022
PubMed

Insights

Precision medicine offers tailored treatments for cancer but lags in rheumatic diseases like rheumatoid arthritis. Addressing challenges in pathogenesis understanding, treatment response, and trial design can close this

Area of Science:

  • Rheumatology and Precision Medicine
  • Translational Research in Autoimmune Diseases

Background:

  • Precision medicine has revolutionized oncology with patient-tailored therapies.
  • Rheumatic diseases, including rheumatoid arthritis, have not seen similar advances.
  • Current rheumatoid arthritis treatment often relies on trial-and-error approaches.

Purpose of the Study:

  • To introduce and define the 'precision gap' in rheumatic diseases.
  • To identify key factors hindering precision medicine adoption in rheumatology.
  • To propose solutions for accelerating precision medicine in rheumatic conditions.

Main Methods:

  • Conceptual analysis of the 'precision gap' in rheumatic diseases.
  • Identification of thematic barriers to precision medicine implementation.
  • Review of current approaches in rheumatoid arthritis treatment and trial design.

Main Results:

  • Four major themes impede progress in rheumatic disease precision medicine.
  • These themes include understanding disease pathogenesis, assessing treatment response, confounding factors, and clinical trial design.
  • Addressing these themes is crucial for closing the precision gap.

Conclusions:

  • Significant challenges remain in translating precision medicine to rheumatic diseases.
  • A multi-faceted approach addressing fundamental scientific and clinical hurdles is necessary.
  • Closing the precision gap will enable more effective, personalized treatments for patients with rheumatic diseases.

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