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Related Concept Videos

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Related Experiment Video

Updated: Aug 26, 2025

In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue
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Hypoglossal Nerve Stimulation Therapy.

Philipp Arens1, Toni Hänsel2, Yan Wang3

  • 1Department of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. philipp.arens@charite.de.

Advances in Experimental Medicine and Biology
|October 10, 2022
PubMed
Summary
This summary is machine-generated.

Hypoglossal nerve stimulation (HNS) is a safe and effective treatment for moderate-to-severe obstructive sleep apnea (OSA). This therapy shows significant improvements in reducing apnea events and daytime sleepiness, establishing it as a valuable option for patients.

Keywords:
Hypoglossal nerve stimulation therapyNeurostimulationObstructive sleep apnea

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Area of Science:

  • Medical Devices
  • Neurosurgery
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is a common sleep disorder.
  • Traditional treatments for OSA may not be effective for all patients.
  • Hypoglossal nerve stimulation (HNS) has emerged as a promising alternative therapy.

Purpose of the Study:

  • To review the development and efficacy of hypoglossal nerve stimulation (HNS) for treating obstructive sleep apnea (OSA).
  • To highlight the evolution of HNS devices from early concepts to modern implantable systems.
  • To establish HNS as an established and developing surgical therapy for OSA.

Main Methods:

  • Review of historical development of HNS for OSA.
  • Analysis of clinical trials and meta-analyses on HNS efficacy.
  • Discussion of technological advancements in HNS devices.

Main Results:

  • HNS is a safe alternative for moderate-to-severe OSA.
  • Meta-analysis shows surgical success rates of 55-75%.
  • Significant reductions in apnea-hypopnea index (AHI) and Epworth Sleepiness Scale (ESS) scores observed.

Conclusions:

  • Hypoglossal nerve stimulation (HNS) is an established treatment for OSA when standard therapies fail.
  • Continuous development in HNS technology offers improved therapeutic options.
  • HNS represents a rapidly advancing field in surgical OSA treatment.