The Neuroprotective Potential of Endophytic Fungi and Proposed Molecular Mechanism: A Current Update

Area of Science:

• Neuroscience and Pharmacology
• Natural Product Chemistry
• Microbiology

Background:

• Neurodegenerative disorders are a leading cause of death globally, impacting millions.
• Common conditions include Alzheimer's disease, Parkinson's disease, and autism, leading to cognitive and motor impairments.
• Natural compounds, particularly polyphenols from various sources, have a history in traditional medicine.

Purpose of the Study:

• To review the pharmacological and clinical potential of endophytic fungi for neuroprotection.
• To explore the molecular mechanisms underlying the neuroprotective effects of endophyte-derived compounds.
• To highlight the current state of research on these bioactive compounds.

Main Methods:

• Literature review of scientific evidence on endophytic fungi and neuroprotection.
• Analysis of studies detailing bioactive compounds, their pharmacological actions, and proposed mechanisms.
• Synthesis of information on clinical and preclinical findings.

Main Results:

• Endophytes produce polyphenols with significant neuroprotective capabilities.
• These compounds can modulate multiple therapeutic targets relevant to neurodegenerative diseases.
• Evidence suggests potential for managing complex neurological conditions.

Conclusions:

• Endophytic fungi represent a promising source of novel neuroprotective agents.
• Further investigation into their bioactive compounds and mechanisms is warranted.
• These natural products offer a potential avenue for managing debilitating neuronal disorders.