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Published on: August 22, 2022
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Primary failure of eruption and tooth resorption
Céline Stutz1, Delphine Wagner2,3,4,5, Catherine-Isabelle Gros1,2,4,6
1Inserm, UMR 1260 Nanomédecine régénérative, Centre de Recherche en Biomédecine de Strasbourg, 1 rue Eugène Boeckel, 67000 Strasbourg, France
L' Orthodontie Francaise
|October 11, 2022
Summary
Primary failure of eruption (PFE) involves tooth eruption failure and can lead to ankylosis and root resorption, even without orthodontic treatment. Understanding PFE
Area of Science:
- Dentistry
- Orthodontics
- Genetics
Background:
- Primary failure of eruption (PFE) is a rare condition characterized by unerupted posterior teeth without mechanical obstruction.
- PFE is linked to PTHR1 gene variants affecting bone metabolism.
- The association between PFE and bone remodeling abnormalities like external root resorption is not well-established.
Purpose of the Study:
- To investigate the biological mechanisms underlying PFE.
- To explore the relationship between PFE, ankylosis, and external root resorption.
- To refine diagnostic and prognostic criteria for PFE.
Main Methods:
- Histological analysis of extracted human teeth affected by PFE.
- Correlation of histological findings with pre-operative cone-beam computed tomography (CBCT) imaging.
- Evaluation of ankylosis and external root resorption in PFE teeth.
Main Results:
- Histological and radiographic analyses confirmed ankylosis in PFE patients, irrespective of orthodontic treatment history.
- Extensive external root replacement resorption was detected in the affected teeth.
- Findings question the direct causal role of orthodontic traction in initiating ankylosis in PFE.
Conclusions:
- Teeth affected by PFE are prone to developing ankylosis and external root resorption.
- Orthodontic treatment may act as an aggravating factor, accelerating or triggering these processes prematurely.
- Understanding PFE's biological basis is crucial for improved patient management.
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