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Tixagevimab/cilgavimab for prevention and treatment of COVID-19: a review

Andrew Ustianowski1

  • 1Regional Infectious Diseases Unit, North Manchester General Hospital and Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK.

Expert Review of Anti-Infective Therapy
|October 11, 2022
PubMed
Abstract

Insights

Tixagevimab/cilgavimab offers crucial protection against COVID-19 for unvaccinated or poorly responding individuals. This review examines its real-world effectiveness and safety, especially for vulnerable populations facing new SARS-CoV-2 variants.

Area of Science:

  • Immunology
  • Virology
  • Pharmacology

Background:

  • Vulnerable populations, including the immunocompromised, require protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) due to inadequate vaccine response.
  • The emergence of new SARS-CoV-2 variants necessitates ongoing strategies for prophylaxis.
  • Tixagevimab/cilgavimab is the sole monoclonal antibody combination authorized for pre-exposure prophylaxis of coronavirus disease 2019 (COVID-19).

Conclusions:

  • Tixagevimab/cilgavimab is vital for protecting individuals with poor vaccine response or contraindications to vaccination.
  • Further research is needed on pediatric use, optimal dosing against variants, and vaccination intervals.
  • Anticipation of potential resistant SARS-CoV-2 variants is crucial for future strategies.
Keywords:
COVID-19CilgavimabOmicronSARS-CoV-2immunocompromisedpre-exposure prophylaxistixagevimabtreatment

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