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Updated: Aug 26, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Left atrial dysfunction as the major driver of heart failure with preserved ejection fraction syndrome
Artem G Ovchinnikov1,2, Alexandra Potekhina1, Evgeny Belyavskiy3
1Out-Patient Department, Institute of Clinical Cardiology, National Medical Research Center of Cardiology named after Academician E.I. Chazov, Moscow, Russia.
Abstract:
Left atrial (LA) dysfunction seems to play a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), is associated with disease severity and poor outcomes and potentially impacts management. Identifying LA myopathy can help guide tailored therapy for HFpEF. Echocardiography allows the accurate measurement of atrial size and function, where LA strain appears to be a sensitive measure of intrinsic LA myopathy. Several therapies and devices that decompress of left atrium are being tested for HFpEF. Further investigation is required to understand the specific atrial effects of statins, mineralocorticoid receptor antagonists, and other therapies.
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