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Motor Unit Stimulation

Motor Unit Stimulation

When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...

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Related Experiment Video

Updated: Aug 26, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Precise motor rhythmicity relies on motor network responsivity.

Kazumasa Uehara^1,2,3, Hiroki Togo^1,4, Takashi Hanakawa^1,4

¹Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 1878551, Japan.

Cerebral Cortex (New York, N.Y. : 1991)

|October 11, 2022

Summary

Human motor rhythmicity control involves two main types of tempo-precision trade-offs. Tunable interhemispheric connectivity in the brain

Keywords:

individual variability motor rhythmicity primary motor cortex resting-state connectivity task-evoked functional connectivity

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Last Updated: Aug 26, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Published on: July 24, 2019

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

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Published on: September 13, 2015

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Area of Science:

Neuroscience
Motor Control
Human Behavior

Background:

Rhythmic movements are fundamental to human behavior.
The central nervous system's control of motor rhythmicity is complex and not fully understood.
Interindividual differences in rhythmic movement control exist.

Purpose of the Study:

To model behavioral differences in tempo-dependent rhythmicity.
To identify distinct types of tempo-precision trade-offs in motor control.
To investigate the neural substrates underlying these behavioral variations.

Main Methods:

Developed a novel tempo-precision trade-off paradigm.
Modeled interindividual differences in rhythmicity across various external tempi.
Utilized task and resting-state functional magnetic resonance imaging (fMRI) to examine neural correlates.

Main Results:

Identified two extreme behavioral types: conventional and paradoxical tempo-precision trade-off.
Found that interhemispheric motor network connectivity varied with tempo.
Paradoxical type showed low baseline connectivity that increased with tempo; conventional type had high baseline connectivity with low responsivity.

Conclusions:

Tunable interhemispheric connectivity is crucial for tempo-dependent rhythmicity control.
Brain network adaptability underlies different strategies for maintaining rhythmic precision.
These findings offer insights into the neural basis of motor coordination and behavioral flexibility.