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Measuring and Improving Adherence to Crisaborole 2% Ointment in Patients With Atopic Dermatitis
Journal of Drugs in Dermatology : JDD
|October 11, 2022
Summary
Medication adherence for atopic dermatitis (AD) was low in a study assessing an internet-based survey. The survey did not improve adherence, but more adults in the intervention group completed the study.
Area of Science:
- Dermatology
- Clinical Trials
- Health Informatics
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by dry, itchy skin.
- Poor medication adherence is a significant factor contributing to treatment failure in AD management.
Purpose of the Study:
- To evaluate the effectiveness of an internet-based survey intervention on improving adherence to topical crisaborole 2% ointment in patients with mild atopic dermatitis.
- To assess the impact of regular email-based adherence reminders on patient engagement and study completion.
Main Methods:
- A randomized controlled trial was conducted with participants assigned to either an intervention group receiving adherence surveys or a control group.
- The intervention group received weekly email surveys for 6 weeks, followed by monthly surveys for 12 months.
- All participants attended 5 in-person study visits over a one-year period.
Main Results:
- Overall medication adherence was low across both adult and pediatric participants.
- No statistically significant difference in adherence rates was observed between the intervention and control groups for either adults (45% vs. 49%) or pediatrics (29% vs. 27%).
- A higher proportion of adult participants in the intervention group completed the study compared to the control group.
Conclusions:
- The internet-based survey intervention did not significantly improve medication adherence in patients with mild atopic dermatitis.
- Low adherence remains a challenge in managing AD.
- Continued provider communication may foster patient support and enhance treatment persistence, as suggested by improved adult retention in the intervention group.
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