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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Carbohydrate Metabolism01:36

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Insulin: Biosynthesis, Chemistry, and Preparation01:25

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Isolation of Human Islets from Partially Pancreatectomized Patients
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Type 3c: Understanding pancreatogenic diabetes.

Jennifer Shurney Vonderau1, Chirag S Desai

  • 1Jennifer Shurney Vonderau is a clinical assistant professor in the PA program at the University of North Carolina at Chapel Hill, N.C. Chirag S. Desai is a professor of surgery, surgical director of liver transplant, and director of chronic pancreatitis and autologous islet cell transplant in the Department of Surgery, Division of Abdominal Transplant at the University of North Carolina Medical Center in Chapel Hill. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|October 11, 2022
PubMed
Summary

Type 3c diabetes, or pancreatogenic diabetes, results from pancreatic islet damage and is often misdiagnosed. It differs from type 2 diabetes in cause, presentation, treatment, and prognosis, carrying higher risks of hypoglycemia complications.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pancreatic Diseases

Background:

  • Type 3c diabetes, also known as pancreatogenic diabetes, arises from primary pancreatic disorders affecting the islets of Langerhans.
  • It is frequently misdiagnosed as type 2 diabetes, leading to potential treatment and management disparities.
  • This condition affects an estimated 5% to 10% of all individuals diagnosed with diabetes.

Conclusions:

  • Accurate diagnosis of type 3c diabetes is crucial for appropriate patient care.
  • Understanding its unique pathophysiology is key to preventing complications.
  • Further research and clinical awareness are needed to improve outcomes for patients with pancreatogenic diabetes.