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Updated: Jan 28, 2026

Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry
Published on: April 8, 2020
A fast algorithm for the computation of the plasma concentration time curve and confidence limits in linear
Abstract:
An algorithm is developed for the computation of the plasma concentration time curve for a drug administration regime involving fast injection (bolus) and/or continuous infusion. The effect of the pharmacokinetic model parameter variations on the plasma concentration time curve is analyzed and efficient algorithms for the computation of the parameter-induced first-order variation and confidence bounds of the plasma concentration time curve are also presented. The application of the method is illustrated with pharmacokinetic data for the etomidate.
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