Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A nonlinear modeling procedure applied to hippocampal convulsant activity.

L W Jennings, H J Doller

    Computers and Biomedical Research, an International Journal
    |August 1, 1987
    PubMed
    Summary

    This study presents a new method for analyzing complex biological data, like brain cell activity during seizures. The damped sine-wave model accurately quantifies seizure activity and drug effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Proposed Diagnostic Criteria for Chronic Antibody-Mediated Rejection in Liver Allografts.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    Impact of IgG3 subclass and C1q-fixing donor-specific HLA alloantibodies on rejection and survival in liver transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    Monoamine concentrations in brain regions of the developing rabbit.

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
    Same author

    De novo donor-specific HLA antibodies decrease patient and graft survival in liver transplant recipients.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
    Same author

    Limiting hepatitis C virus progression in liver transplant recipients using sirolimus-based immunosuppression.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
    Same author

    High mean fluorescence intensity donor-specific anti-HLA antibodies associated with chronic rejection Postliver transplant.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011

    Area of Science:

    • Neuroscience
    • Computational Biology
    • Biophysics

    Background:

    • Picrotoxin-induced rhythmic discharges in CA1 cells of hippocampal slices exhibit complex nonlinear dynamics.
    • Quantifying seizure activity and drug effects requires sophisticated modeling approaches.

    Purpose of the Study:

    • To develop and demonstrate a strategy for fitting complex nonlinear models to experimental biological data.
    • To apply a damped sine-wave model for quantifying seizure activity and the effects of convulsant/anticonvulsant drugs.

    Main Methods:

    • A strategy for fitting complex nonlinear models to experimental data was developed.
    • Preliminary models were fitted to extreme data values and half-wave frequency estimates to determine time dependency.
    • An exponential damping model was identified for both amplitude and frequency components.

    Related Experiment Videos

  • Parameter estimates from preliminary models served as starting values for a simultaneous nonlinear fit using all data.

    • Main Results:

    • The procedure was demonstrated using an amplitude and frequency damped sine wave.
    • An exponential damping model effectively fit the time dependency of amplitude and frequency.
    • The damped sine-wave model describes the response using six parameters: linear trend (slope, intercept) and sinusoidal component (amplitude, amplitude decay, frequency, frequency decay).

    Conclusions:

    • The developed strategy provides a robust method for analyzing complex nonlinear biological data.
    • The damped sine-wave model offers a quantitative approach to characterizing seizure activity.
    • This model has potential applications in evaluating the efficacy of convulsant and anticonvulsant drugs.