Combined action of indomethacin and adrenalin on morphofunctional heart indicators

The influence of simultaneous administration of indomethacin and adrenalin on heart microcirculation, myocardial blood flow, peroxide lipid oxidation in the heart muscle homogenate and myocardial contractility was studied in male albino rats and in the myocardium of 6-7 days old chicken embryos. Intramuscular adrenalin administration in a dosis of 2 mg/kg led to a considerable reduction of the exchange surface of the capillaries and to a slow-down of blood flow in myocardial tissue, an increase in the lipid peroxide content in the heart muscle, and to an acceleration of the heart rate with the development of arrhythmia. Indomethacin abolished haemodynamic and metabolic myocardial disorders generated by toxic doses of adrenalin hydrochloride. It had also a cardiotonic and anti-arrhythmic effect: it abolished arrhythmia brought about by aconitine and adrenalin in the culture of the embryonal chicken myocardium explantate. These up to the present unknown cardiotonic, anti-arrhythmic and adrenoprotective properties of indomethacin can contribute to a substantial broadening of its therapeutical application.