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Updated: Aug 26, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Microbiome and Allergy: New Insights and Perspectives
E Zubeldia-Varela1,2, T C Barker-Tejeda1,2, D Obeso1,2
1Institute of Applied Molecular Medicine (IMMA), Department of Basic Medical Sciences, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
Journal of Investigational Allergology & Clinical Immunology
|October 11, 2022
Summary
The human microbiome, an altered composition of microbes, influences immune responses and allergies. Understanding gut, skin, and lung microbiota is key to developing new allergy prevention strategies.
Area of Science:
- Immunology
- Microbiology
- Genetics
Background:
- The human microbiome's role in allergy development is increasingly recognized.
- Microbiota dysbiosis is linked to immune system alterations and specific allergic diseases.
- Factors like diet and lifestyle dynamically shape microbiota composition.
Purpose of the Study:
- To review recent advances in human microbiota research concerning allergy.
- To explore the relationship between the microbiome and immune system in allergic diseases.
- To discuss microbiome analysis technologies and intervention strategies for allergy prevention.
Main Methods:
- Literature review focusing on intestinal, cutaneous, and respiratory microbiota.
- Analysis of 'omics' techniques for microbiota study.
- Examination of intervention mechanisms targeting the microbiota.
Main Results:
- Established links between lung microbiota and respiratory allergy.
- Established links between skin microbiota and atopic dermatitis.
- Established links between gut microbiota and food allergy.
Conclusions:
- Microbiome research is crucial for understanding and potentially preventing allergies.
- Advanced 'omics' technologies are vital for studying complex host-microbiota interactions.
- Targeting the microbiome offers promising avenues for future allergy interventions.
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