Interactions between nutrient intake and comorbidities for quality of life in premenopausal and postmenopausal women

This study aimed to identify the associations between nutrient intake and health-related quality of life (HRQOL) in premenopausal and postmenopausal women.

Using data from Korean National Health and Nutrition Examination Surveys (2019-2020), EQ-5D-3L, and multivariate logistic and linear regression models, we analyzed the association and interaction between nutrient intake, comorbidities, and HRQOL among 4,027 Korean women.

Nutrient intake levels were lower in postmenopausal women than in premenopausal women. Interactions were observed between numerous nutrient intakes and comorbidities for HRQOL among premenopausal and postmenopausal women. Higher intakes of various nutrients (particularly, folic acid and vitamin A) were related to higher HRQOL scores in premenopausal women with comorbidities (log of inverse HRQOL scores, β = -0.31 [95% confidence interval [CI], -0.58 to -0.05] and β = -0.19 [95% CI, -0.37 to -0.001]) and postmenopausal women with comorbidities (log of inverse HRQOL scores, β = -0.34 [95% CI, -0.61 to -0.07] and β = -0.19 [95% CI, -0.38 to -0.01]), respectively. Regular exercise was associated with a lower risk of mobility problems (odds ratio [OR], 0.59; 95% CI, 0.44-0.81), self-care problems (OR, 0.53; 95% CI, 0.28-0.99), usual activity problems (OR, 0.42; 95% CI, 0.26-0.67), and any problem (OR, 0.71; 95% CI, 0.56-0.90), as well as an increase in HRQOL score (log of inverse HRQOL scores, β = -0.42; 95% CI, -0.68 to -0.16) in postmenopausal women. Smoking was related to a higher prevalence of depression and anxiety problems (OR, 2.51; 95% CI, 1.53-4.13) and any problem (OR, 1.67; 95% CI, 1.11-2.52), as well as a decrease in HRQOL scores (log of inverse HRQOL scores, β = 0.51; 95% CI, 0.14-0.88) in premenopausal women.

Given the lower nutrient intake levels in postmenopausal women, it is critical to establish HRQOL-improving approaches for this population, including regular exercise, nutrient intake, and smoking cessation.