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Related Experiment Video

Updated: Aug 26, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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[Advances on optic disc morphological features and peripapillary structure changes in high myopia].

W Q Tang¹, F Nie², D M Zhou²

¹Department of Ophthalmology, Hunan Children's Hospital, Changsha 410007, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology

|October 11, 2022

Summary

High myopia, a leading cause of vision loss, involves axial length elongation and posterior pole degeneration. This review examines optic disc and peripapillary changes to understand high myopia pathogenesis.

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Published on: July 24, 2020

Area of Science:

Ophthalmology
Medical Research

Background:

High myopia is a significant global cause of low vision and blindness.
It is characterized by axial length elongation and degenerative changes in the fundus posterior pole.

Purpose of the Study:

To review optic disc morphological features in high myopia.
To examine peripapillary structure changes associated with high myopia.
To elucidate the pathogenesis of high myopia and inform prevention/treatment strategies.

Main Methods:

Literature review of studies on high myopia.
Analysis of optic disc morphology.
Assessment of peripapillary structure alterations.

Main Results:

High myopia presents with optic disc tilt, altered optic cup and rim.
Degenerative changes include chorioretinal atrophy, posterior staphyloma, and intrachoroidal cavitation.
These changes are linked to prolonged axial length.

Conclusions:

Optic disc and peripapillary changes are key features of high myopia.
Understanding these morphological alterations is crucial for advancing prevention and treatment.
Further research into pathogenesis may yield novel therapeutic approaches.