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Trans-Compartmental Regulation of Tight Junction Barrier Function
Amna N Naser1, Qun Lu1, Yan-Hua Chen1
1Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University Greenville, Greenville, North Carolina, USA.
Tissue Barriers
|October 11, 2022
Summary
This review explores how cell junctions like tight junctions (TJs), adherens junctions (AJs), and gap junctions (GJs) interact. It highlights how AJ and GJ proteins influence TJ barrier function in various biological systems.
Area of Science:
- Cell biology
- Epithelial biology
- Membrane protein interactions
Background:
- Tight junctions (TJs) form apical barriers in epithelial and endothelial cells, controlling paracellular passage.
- Adherens junctions (AJs) mediate cell-cell adhesion and signaling, while gap junctions (GJs) regulate intercellular communication.
- TJ barrier function relies on proteins like claudins and occludins, but other junctional proteins also play regulatory roles.
Conclusions:
- Cellular activities are modulated through the crosstalk between tight, adherens, and gap junctions.
- Understanding these interactions is key to comprehending epithelial and endothelial cell function.
- Further research into junctional crosstalk can reveal new therapeutic targets.
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