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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Association between serum klotho levels and cardiovascular disease risk factors in older adults
Jaeho Lee1,2, Donghoon Kim1,2, Hyo-Jung Lee1
1Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
Insights
Lower serum klotho levels are linked to increased cardiovascular disease (CVD) risk factors like obesity, smoking, and unhealthy lipid profiles. Soluble klotho may serve as a potential biomarker for predicting CVD risk.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Biochemistry
Background:
- Klotho deficiency is a known predictor of cardiovascular disease (CVD) mortality and morbidity.
- Limited research exists on the association between klotho and individual CVD risk factors.
- This study investigates the relationship between serum klotho levels and CVD risk factors in adults.
Purpose of the Study:
- To explore the association between circulating serum klotho levels and various cardiovascular disease risk factors in adults.
- To determine if serum klotho levels correlate with factors such as BMI, smoking, alcohol consumption, and lipid parameters.
Main Methods:
- Utilized data from 13,154 participants in the 2007-2016 National Health and Nutrition Examination Survey.
- Assessed serum klotho levels and considered risk factors including BMI, exercise, smoking, alcohol consumption, hypertension, dyslipidemia, lipids, and blood pressure.
Main Results:
- Lower serum klotho levels were associated with higher BMI (overweight/obesity), current smoking, and alcohol consumption.
- Serum klotho levels were positively associated with no history of dyslipidemia.
- Decreased klotho levels correlated with elevated triglycerides and total cholesterol, with non-linear relationships observed.
Conclusions:
- Reduced serum klotho levels are linked to key cardiovascular disease risk factors.
- The findings suggest that soluble klotho may function as a potential biomarker for cardiovascular disease risk assessment.
Background:
Klotho deficiency is a significant predictor of cardiovascular disease (CVD)-related mortality and morbidity. However, research assessing the association between klotho and individual risk factors of CVD is limited. This study aimed to explore the association between circulating serum klotho levels and risk factors for CVD in adults.
Methods:
We used the 2007-2016 National Health and Nutrition Examination Survey and included 13,154 participants for whom serum klotho levels were available. Body mass index (BMI), exercise, smoking status, alcohol consumption, hypertension, dyslipidemia, serum lipid parameters, and blood pressure were considered as CVD risk factors.
Results:
Circulating klotho levels were negatively associated with being overweight (beta coefficient: - 22.609, p = 0.0025), obesity (beta coefficient: - 23.716, p = 0.0011), current smoking (beta coefficient: - 46.412, p < 0.0001), and alcohol consumption (beta coefficient: - 51.194, p < 0.0001). There was a positive association between serum klotho levels and no history of dyslipidemia (beta coefficient: 15.474, p = 0.0053). Serum klotho levels were significantly decreased by a unit increase in triglycerides (beta coefficient: - 0.117, p = 0.0006) and total cholesterol (beta coefficient: - 0.249, p = 0.0002). There was a significant non-linear relationship between serum klotho levels, triglycerides, and total cholesterol.
Conclusions:
Lower serum klotho levels are associated with certain CVD risk factors, including high BMI, smoking, alcohol consumption, and lipid parameters (triglycerides and total cholesterol). This study suggests that the soluble klotho level may be a potential marker for CVD risk.
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