Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.4K
Tumor Progression02:07

Tumor Progression

6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

12.5K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.5K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histologic margin involvement by cutaneous basal cell carcinoma stroma: a retrospective cohort study for residual or recurrent carcinoma.

Journal of clinical pathology·2026
Same author

A Rapid Drug-Induced Granulomatous Dermatitis to Amlodipine.

The American journal of cardiology·2026
Same author

Response to Critical Insights on the Article: Colloid Bodies in Cutaneous Basal Cell Carcinoma: Clinical and Histologic Correlates-An Analysis of 405 Cases.

Journal of cutaneous pathology·2025
Same author

Perianal Crohn's Disease Successfully Treated With Topical Ruxolitinib.

The Journal of dermatology·2025
Same author

Immunotherapy-associated bullous and oral erosive lichenoid eruption successfully treated with hydroxychloroquine.

JAAD case reports·2025
Same author

Martin C. Mihm, Jr. and Dermatopathology Education at Harvard Medical School.

Journal of cutaneous pathology·2025

Related Experiment Video

Updated: Aug 26, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K

Clonal-pattern Seborrheic Keratosis: Risk of Recurrence and Progression to Carcinoma.

Joshua F Goldsmith1, Laleh Montaser Kouhsari, Steven R Tahan

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

The American Journal of Surgical Pathology
|October 12, 2022
PubMed
Summary

Incompletely excised clonal seborrheic keratoses (CPSK) have a higher recurrence rate than other subtypes. CPSK with atypia showed a significant risk of progressing to squamous cell carcinoma (SCC).

More Related Videos

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.6K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.5K

Related Experiment Videos

Last Updated: Aug 26, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.6K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.5K

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Seborrheic keratosis (SK) is a common benign epidermal tumor.
  • Clonal pattern seborrheic keratosis (CPSK) is a distinct subtype with unique histologic features.
  • Incomplete excision of SKs raises concerns for recurrence and malignant transformation.

Purpose of the Study:

  • To quantitatively assess the risk of recurrence and progression to squamous cell carcinoma (SCC) in incompletely excised CPSKs.
  • To compare recurrence and progression rates between CPSKs with and without cytologic atypia.
  • To compare CPSKs with non-CPSK subtypes regarding recurrence and malignant potential.

Main Methods:

  • Retrospective study of 244 CPSK cases and 107 non-CPSK controls diagnosed between 2008-2018.
  • Incompletely excised lesions were analyzed for recurrence and progression.
  • CPSK lesions were categorized into those with and without cytologic atypia.
  • Follow-up data were collected from electronic health records, with a minimum follow-up of 2 years.

Main Results:

  • Incompletely excised CPSKs recurred in 7.4% of cases, compared to 1.9% for non-CPSKs (P=0.04).
  • CPSK with atypia demonstrated a higher recurrence rate than CPSK without atypia (P=0.03).
  • Of recurrent CPSKs with atypia, 78% progressed to SCC (in situ or invasive).

Conclusions:

  • Clonal pattern seborrheic keratosis, particularly with atypia, has a significant risk of recurrence and progression to SCC after incomplete excision.
  • Pathologists should report the presence of clonal patterns, atypia, and margin status in SK diagnoses.
  • Close follow-up and complete excision are recommended for CPSKs, especially those with cytologic atypia.