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Reference intervals of complete blood count parameters for individuals aged 80 to 89 years in Guizhou, China: A
Jinlie Long1,2, Xiuhong Wang3, Jianbo Yuan1,2
1Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Insights
This study establishes new reference intervals for complete blood count (CBC) parameters in healthy adults aged 80-89 in Guizhou, China. These localized findings reveal sex-specific differences and lower values compared to national standards, crucial for accurate geriatric diagnosis.
Area of Science:
- Geriatric Medicine
- Clinical Hematology
- Population Health
Background:
- Standard complete blood count (CBC) reference intervals (20-79 years) are suboptimal for diagnosing older adults.
- Existing Chinese reference intervals for the elderly lack specific data from Guizhou province.
- Accurate CBC reference intervals are vital for effective clinical decision-making in the elderly population.
Purpose of the Study:
- To establish population-based reference intervals for CBC parameters in healthy adults aged 80-89 years in Guizhou, China.
- To investigate sex-specific differences in CBC parameters within this elderly cohort.
- To compare local reference intervals with existing national standards for geriatric populations.
Main Methods:
- Recruited 481 healthy adults (238 males, 243 females) aged 80-89 years in Guizhou.
- Analyzed CBC parameters using a Sysmex XN-9000 automated hematology analyzer.
- Determined reference intervals following International Federation of Clinical Chemistry guidelines.
Main Results:
- Established local reference intervals for CBC parameters in Guizhou's elderly population (80-89 years).
- Identified significant sex-specific differences in several CBC parameters, particularly RBC-related ones.
- Observed that most established reference intervals were lower than current national standards.
Conclusions:
- The study provides crucial, localized CBC reference intervals for the 80-89 age group in Guizhou.
- Sex-specific reference intervals are necessary, especially for red blood cell parameters.
- The identified lower values compared to national standards necessitate careful clinical interpretation for improved geriatric diagnosis and management.
Abstract:
The reference intervals of complete blood count (CBC) parameters were commonly based on healthy individuals aged 20 to 79 years. However, these values are not optimal for correct clinical diagnosis in older individuals (e.g., 80-89 years). Although the reference intervals for this age group have been reported in China, there is no population-based report in Guizhou province. A total of 481 healthy adults (238 males and 243 females) aged 80 to 89 years were recruited from Affiliated Hospital of Zunyi Medical University in Guizhou. The CBC parameters were detected by Sysmex XN-9000 automatic hematology analyzer. The reference intervals of the components were analyzed according to the guidelines of International Federation of Clinical Chemistry. This study reported the reference intervals of CBC parameters. There were significant differences were examined in some reference intervals between the different gender groups, especially for RBC-related parameters. Compared with national standards, the most of all conventional reference intervals for CBC parameters were decreased. The present study provided the local reference intervals of CBC parameters for individuals aged 80 to 89 years in Guizhou, China. Some of our results were sex-specific, and most of our results show lower values while comparing with commonly used reference intervals in China. Therefore, more attentions should be paid to these differences, and accurate reference intervals will facilitate clinical diagnosis and decision-making in these populations.
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