Related Experiment Video
Updated: Aug 26, 2025
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Estimation of biochemical factors affecting survival in intensive care COVID-19 patients undergoing chest CT scoring:
Hakan Dal1, Esra Sultan Karabulut Keklik1, Hakan Yilmaz2
1Department of Intensive Care Unit, Uşak Research and Training Hospital, Uşak, Turkey.
Insights
This study found that while longer ICU stays, mechanical ventilation, and higher blood urea nitrogen levels were linked to COVID-19 mortality, chest CT scores were not. Prognosis in COVID-19 patients is complex and requires further investigation.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Radiology
Background:
- Coronavirus disease 2019 (COVID-19) rapidly spread globally, leading to a pandemic and increased focus on mortality and prognosis.
- Evaluating factors influencing survival in critically ill COVID-19 patients is crucial for effective management.
Purpose of the Study:
- To identify factors affecting the survival of COVID-19 patients in a tertiary intensive care unit (ICU).
- To investigate the association between chest computed tomography (CT) scoring and mortality in COVID-19 patients.
Main Methods:
- Retrospective cross-sectional study of 187 symptomatic patients with suspected COVID-19 admitted to the ICU.
- Data collected included demographics, APACHE II scores, chest CT findings, RT-PCR results, and laboratory parameters.
- Statistical analysis was performed using SPSS, with significance assessed at P < .05.
Main Results:
- Of 187 patients, 86 (46.0%) tested positive for COVID-19, and 110 (58.8%) died.
- Nonsurvivors had significantly longer ICU stays, greater invasive mechanical ventilation time, and higher blood urea nitrogen (BUN) levels.
- Patients with an APACHE II score of 23 or higher had a 1.12-fold increased mortality rate; however, total chest CT score did not significantly correlate with mortality.
Conclusions:
- ICU stay, mechanical ventilation duration, and BUN levels are significant factors associated with mortality in COVID-19 patients.
- Chest CT score is not a significant predictor of mortality in this patient cohort.
- Further research is needed to identify reliable prognostic markers for COVID-19, especially with emerging variants.
Abstract:
Coronavirus disease 2019 (COVID-19) is a rapidly spreading deadly respiratory disease that emerged in the city of Wuhan in December 2019. As a result of its rapid and widespread transmission, the WHO declared a pandemic on March 11, 2020 and studies evaluating mortality and prognosis in COVID-19 gained importance. The aim of this study was to determine the factors affecting the survival of COVID-19 patients followed up in a tertiary intensive care unit (ICU) and undergoing chest computed tomography (CT) scoring. This retrospective cross-sectional study was conducted with the approval of Uşak University Medical Faculty Ethics Committee between July and September 2020. It included 187 symptomatic patients (67 females, 120 males) with suspected COVID-19 who underwent chest CT scans in the ICU. Demographics, acute physiology and chronic health evaluation (APACHE II), chest CT scores, COVID-19 real-time polymerase chain reaction (RT PCR) results, and laboratory parameters were recorded. SPSS 15.0 for Windows was used for the data analysis. The ages of the patients ranged from 18 to 94 and the mean age was 68.0 ± 13.9 years. The COVID-19 RT PCR test was positive in 86 (46.0%) patients and 110 patients (58.8%) died during the follow-up. ICU stay (P = .024) and total invasive mechanical ventilation time (P < .001) were longer and blood urea nitrogen (BUN) was higher (P < .001) in the nonsurvivors. Patients with an APACHE II score of 23 and above had a 1.12-fold higher mortality rate (95% CI 0.061-0.263). There was no significant difference in total chest CT score between the survivors and nonsurvivors (P = .210). Chest CT score was not significantly associated with mortality in COVID-19 patients. Our idea that COVID-19 will cause greater mortality in patients with severe chest CT findings has changed. More studies on COVID-19 are needed to reveal the markers that affect prognosis and mortality in this period when new variants are affecting the world.
More Related Videos
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:20Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
01:28Imaging Studies for Cardiovascular System V: CT