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Association between CARD14 gene polymorphisms and psoriasis vulgaris in Hainan Han population based on exon

Antonia Msafiri Makene1, Jun-Lin Liu

  • 1Department of Dermatology and Venereology. The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.

Medicine
|October 12, 2022
PubMed

Insights

The CARD14 gene is linked to psoriasis vulgaris susceptibility in the Hainan Han population. Specific single nucleotide polymorphisms (SNPs) and haplotypes within CARD14 influence disease risk.

Area of Science:

  • Genetics
  • Immunology
  • Dermatology

Background:

  • Psoriasis is a chronic immune-inflammatory disease affecting 125 million globally, with impacts beyond skin.
  • Genome-wide association studies suggest CARD14 gene variants are associated with psoriasis.
  • Understanding genetic susceptibility is crucial for individualized psoriasis therapy.

Purpose of the Study:

  • To investigate the association between the CARD14 gene and psoriasis vulgaris susceptibility.
  • To identify specific single nucleotide polymorphisms (SNPs) and haplotypes within CARD14 related to psoriasis risk.

Main Methods:

  • Exome sequencing of 101 psoriasis patients and 79 healthy controls.
  • Sequencing of CARD14 gene regions (±1kb upstream/downstream).
  • SNP-based and haplotype-based association analyses, including bioinformatic predictions of SNP impact.

Main Results:

  • Identified 32 polymorphisms, with 3 SNPs (1 exonic, 2 intronic) associated with psoriasis susceptibility (P < .05).
  • Exonic SNP rs144475004 resulted in an amino acid change (Asp to His).
  • Two protective haplotypes (CARD14-1, CARD14-2) showed significantly lower frequencies in patients (1.49%) vs. controls (6.96%).

Conclusions:

  • The CARD14 gene is associated with psoriasis vulgaris susceptibility in the Hainan Han population.
  • Specific CARD14 SNPs and haplotypes may serve as biomarkers for psoriasis risk.
  • Findings contribute to understanding the genetic basis of psoriasis and personalized treatment approaches.

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