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Updated: Aug 26, 2025

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In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
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Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner
Borna Sarker1,2, Sandra M Cardona1,2, Kaira A Church1,2
1Department of Molecular Microbiology and Immunology, 12346The University of Texas at San Antonio, San Antonio, TX, USA.
ASN Neuro
|October 12, 2022
Abstract
Summary Statement:
Diabetic human and murine retinas revealed pronounced microglial morphological activation and vascular abnormalities associated with inflammation. Pharmacological fibrinogen depletion using ancrod dampened microglial morphology alterations, resolved fibrinogen accumulation, rescued axonal integrity, and reduced inflammation in the diabetic murine retina.

